N-of-1 Clinical Trials: Removing the Hay to Find the Needle.

Significant intravascular hemolysis can complicate dialysis (e.g., because of a kink in a dialysis line) and may result in the formation of methemalbumin (1 ). This gives serum a brown appearance, quite distinct from the typical reddish color associated with extravascular hemolysis. In this case, spectrophotometry performed before and after the addition of a reducing agent (sodium dithionite) (2 ) revealed an increase in absorbance at a wavelength of 569 nm, confirming the presence of methemalbumin.